Detection and characterization of interactions of genetic risk factors in disease
Patricia Francis-Lyon
Shashank Belvadi
Fu-Yuan Cheng
Abstract
It is well known that two or more genes can interact so as to enhance or suppress incidence of disease,
such that the observed phenotype differs from when the genes act independently. The effect of a gene allele
at one locus can mask or modify the effect of alleles at one or more other loci. Discovery and characterization
of such gene interactions is pursued as a valuable aid in early diagnosis and treatment of disease.
Also it is hoped that the characterization of such interactions will shed light on biological and biochemical pathways
that are involved in a specific disease, leading to new therapeutic treatments.
Much attention has been focused on the application of machine learning approaches to detection of gene interactions.
Our method is based upon training a supervised learning algorithm to detect disease, and then quantifying the effect
on prediction accuracy when alleles of two or more genes are perturbed to unmutated in patterns so as to reveal and
characterize gene interactions. We utilize this approach with a support vector machine.
We test the versatility of our approach using seven disease models, some of which model gene interactions and some of
which model biological independence. In every disease model we correctly detect the presence or absence of 2-way and
3-way gene interactions using our method. We also correctly characterize all of the interactions as to the epistatic
effect of gene alleles in both 2-way and 3-way gene interactions. This provides evidence that this machine learning approach
can be used to successfully detect and also characterize gene interactions in disease.
machine learning, support vector machine, genetic risk factors, gene interactions
DOI10.25080/Majora-8b375195-007